WASHINGTON http://www.cheapmlbtwinsjerseys.com/zach-duke/ , Aug. 23 (Xinhua) -- Chinese scientists have found a compound that helped a tumor-targeting virus kill liver cancer more effectively while sparing healthy cells, offering new hope for treating the world's second most common cancer killer, according to a study published Wednesday.
A therapy using viruses that selectively kill cancer cells, dubbed oncolytic viruses, is rapidly progressing through clinical evaluation http://www.cheapmlbtwinsjerseys.com/kennys-vargas/ , but the therapeutic efficacy in humans has been less than expected from preclinical studies, according to the study published in the U.S. journal Science Translational Medicine.
Oncolytic virotherapy involving M1 virus, a mosquito-borne pathogen that predominantly causes mild illness in horses, is believed to be a potentially attractive strategy for the treatment of hepatocellular carcinoma (HCC), the most common type of liver cancer.
In order to boost the virus's antitumor effects http://www.cheapmlbtwinsjerseys.com/max-kepler/ , Professor Guangmei Yan of Sun Yat-sen University in China and colleagues screened 350 small molecules to identify compounds that can enhance viral killing of cultured HCC cells.
The researchers found that Eeyarestatin I, an inhibitor of the protein VCP, which has been linked to causing malignancy, as the strongest sensitizer for M1 virus, as it increased the potency of the virus by as much as 3 http://www.cheapmlbtwinsjerseys.com/jason-castro/ ,600-fold against the HCC cells.
The dual regimen had no effect on non-cancerous cells, they said.
In multiple mouse models of HCC, M1 together with Eeyarestatin I were found to shrink tumors and significantly prolong survival.
The researchers further demonstrated that the duo was safe and well-tolerated in monkeys.
"We can describe the M1 oncolytic virus as a guided missile that automatically targets tumor cells, and the addition of the VCP inhibitor is just like binding the missile to powerful explosives with the ability of auto-selection," Yan explained to Xinhua.
"The outcome is self-evident with such a strong combination http://www.cheapmlbtwinsjerseys.com/anibal-sanchez/ ," he said.
Yan said they plan to submit a clinical trial application for the combination therapy strategy in 2018.
"Hepatocellular carcinoma is the second leading cause of cancer-related death in men and claims more than 700,000 lives per year worldwide," their paper wrote. "Our study identifies combined VCP inhibition and oncolytic virus as a potential treatment for HCC and demonstrates promising therapeutic potential."
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BEIJING, April 14 (Xinhua) -- China's fiscal revenue has maintained fast growth since the start of the year on the back of surging prices and a firming economy, official data showed Friday.
Fiscal revenue rose 14.1 percent year on year to 4.44 trillion yuan (645.9 billion U.S. dollars) in the first quarter http://www.cheapmlbtwinsjerseys.com/joe-mauer/ , the Ministry of Finance disclosed at a press conference.
The growth slightly retreated from the 14.9-percent gain seen in the January-February period, but was still markedly above the 4.5-percent rate in 2016.
In March alone, fiscal revenue went up 12.2 percent to 1.29 trillion yuan.
The ministry attributed the continued momentum to rising prices at the factory gate, a firming economy, and recovering exports and imports.
China's producer price index http://www.cheapmlbtwinsjerseys.com/erick-aybar/ , which measures costs of goods at the factory gate, has stayed in positive territory since September last year, when it ended a four-year streak of declines, partly due to the government's successful campaign to cut industrial overcapacity.
The index stayed at an elevated level last month, rising 7.6 percent year on year.
The upward trend in turn boosted industrial profits and economic activities http://www.cheapmlbtwinsjerseys.com/justin-morneau/ , which helped drive growth in tax revenues, according to the ministry.
Friday's data showed taxes collected from the corporate sector went up 18.8 percent due to increasing profits, while taxes from goods imports surged 41.9 percent.
The central government collected 2.02 trillion yuan in fiscal revenue, up 17.1 percent year on year, while local governments saw fiscal revenue expand 11.7 percent to 2.42 trillion yuan.
In the first three months http://www.cheapmlbtwinsjerseys.com/rod-carew/ , fiscal spending surged 21 percent year on year to 4.59 trillion yuan, among which expenditure on affordable housing jumped 46.8 percent to 135.3 billion yuan.
This year China's fiscal deficit is projected to be 3 percent of GDP, or 2.38 trillion yuan, according to the government work report last month.
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Scenery of Hani terraced fields in SW China's Yunnan
Aerial view of farmland scenery in SW China's Yunnan
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